The Muppets are back in a new zany comedy, Muppets from Space. The Muppets embark on a hilarious extra terrestrial adventure in hopes of finding out about Gonzo's family members are aliens from a distant planet! Gonzo then gets a message that his relatives are coming for a visit, from outer space! But when word gets out on Miss Piggy's talk show, UFO Mania, that the friendly aliens are coming, a secret government agency led by K. Edgar Singer (Jeffrey Tambor) captures Gonzo and goes to great lengths to learn when his extra-terrestrial family will arrive. Now only the Muppets, led by Kermit and Miss Piggy, can save Gonzo and make the world safe for a friendly alien invasion!
讲述为了拯救因愤怒和暴力极大化的病毒而成为废墟的地球，分散在另一个次元的少年们聚集在一起寻找希望之星的故事。
卡美拉与卡欧斯决战后的冬天，北海道降下流星雨，其中一颗坠落在支笏湖南西方约一公里处，陆上自卫队第11师团随即派出化学防护小队，渡良瀬佑介二佐与花谷陆尉深入调查，发现到了是陨石坠落。 五天后，事件的原凶开始现身，札幌市地下铁的电车在隧道内被不明生物攻击，北海道札幌市的薄野出现巨大植物，巨大植物窜出一群体长3m，类似昆虫的甲壳类生物。 怪虫(Legion)与植物是与流星一起飞来的地球外物体，两者属共生关系，Legion会借由啃食硅酮并分泌氧气来制造植物(草体)，在这种高浓度氧的环境下，地球生物绝对无法生存，自卫队决定用爆破处理草体。此时海上自卫队探测到卡美拉往札幌飞去........
